Several genes are now available for genetic testing for prostate cancer. These genes can confer varying degree of risk for prostate cancer and risk for additional cancers.

Guidelines for cancer screening, management, and treatment exist for some genes and not for others. It is important for patients to understand their genetic test results in the context of their own personal and family history.

The information described here is intended to provide general guidance regarding cancer risks, screening, risk reducing options, and further management for patients and their families. The information should be placed in context of your personal and family history and discussed with your doctor(s) for personal recommendations and management.

Genes of Relevance to Prostate Cancer

Multiple genes are associated with inherited prostate cancer risk, but the degree of risk can vary by gene. Furthermore, some genes may provide insight regarding risk for aggressive prostate cancer. Prostate cancer treatment, management, or screening recommendations are available for some of these genes but not all. Additional cancer risks may also be identified based upon the genes tested.

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Additional Cancer Risk Genes

Several genes are available for genetic testing, some of which are on prostate cancer panels. Some of these genes may inform treatment or clinical trials for men with prostate cancer, particularly for men with metastatic disease. These genes have additional cancer risks associated, which may be important for cancer screening and management.

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